Multiple-omics analysis of aggrephagy-related cellular patterns and development of an aggrephagy-related signature for hepatocellular carcinoma
Abstract Background Protein aggrephagy, a selected autophagy process response for degrading protein aggregates, plays a critical role in various cancers.However, its regulatory mechanisms and clinical implications in hepatocellular carcinoma (HCC) remain largely unexplored.Methods We integrated bulk RNA-seq data from TCGA and single-cell RNA sequen